References for: doi:10.1038/s41467-022-29206-7

Full identifier: https://doi.org/10.1038/s41467-022-29206-7

Nanopublication Part Subject Predicate Object Published By Published On
links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion
doi:10.1038/s41467-022-29206-7
Johanna Sophie Mück
2025-06-25T12:53:52.514Z
links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion
doi:10.1038/s41467-022-29206-7
Johanna Sophie Mück
2025-06-25T12:53:52.514Z
links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion
doi:10.1038/s41467-022-29206-7
The induction of natural competence adapts staphylococcal metabolism to infection
Johanna Sophie Mück
2025-06-25T12:53:52.514Z
links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion
doi:10.1038/s41467-022-29206-7
2022-03-21
Johanna Sophie Mück
2025-06-25T12:53:52.514Z
links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion
doi:10.1038/s41467-022-29206-7
A central question concerning natural competence is why orthologs of competence genes are conserved in non-competent bacterial species, suggesting they have a role other than in transformation. Here we show that competence induction in the human pathogen Staphylococcus aureus occurs in response to ROS and host defenses that compromise bacterial respiration during infection. Bacteria cope with reduced respiration by obtaining energy through fermentation instead. Since fermentation is energetically less efficient than respiration, the energy supply must be assured by increasing the glycolytic flux. The induction of natural competence increases the rate of glycolysis in bacteria that are unable to respire via upregulation of DNA- and glucose-uptake systems. A competent-defective mutant showed no such increase in glycolysis, which negatively affects its survival in both mouse and Galleria infection models. Natural competence foster genetic variability and provides S. aureus with additional nutritional and metabolic possibilities, allowing it to proliferate during infection.
Johanna Sophie Mück
2025-06-25T12:53:52.514Z
links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion
doi:10.1038/s41467-022-29206-7
13
Johanna Sophie Mück
2025-06-25T12:53:52.514Z
links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion
doi:10.1038/s41467-022-29206-7
2022
Johanna Sophie Mück
2025-06-25T12:53:52.514Z
links a nanopublication to its pubinfo http://www.nanopub.org/nschema#hasPublicationInfo pubinfo
doi:10.1038/s41467-022-29206-7
Johanna Sophie Mück
2025-06-25T12:53:52.514Z
links a nanopublication to its provenance http://www.nanopub.org/nschema#hasProvenance provenance
doi:10.1038/s41467-022-29206-7
Valentin Casas Stöldt
2025-04-09T08:31:26.531Z
links a nanopublication to its provenance http://www.nanopub.org/nschema#hasProvenance provenance
doi:10.1038/s41467-022-29206-7
Valentin Casas Stöldt
2025-04-09T08:31:26.531Z
links a nanopublication to its provenance http://www.nanopub.org/nschema#hasProvenance provenance
doi:10.1038/s41467-022-29206-7
Valentin Casas Stöldt
2025-04-09T08:21:43.622Z
links a nanopublication to its provenance http://www.nanopub.org/nschema#hasProvenance provenance
doi:10.1038/s41467-022-29206-7
Valentin Casas Stöldt
2025-04-09T08:21:43.622Z