http://purl.org/np/RAxAUvPgoe... RAxAUvPgoe

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

http://www.w3.org/1999/02/22-rdf-syntax-ns#type type

https://w3id.org/biolink/vocab...OrPhenotypicFeatureAssociation ChemicalToDiseaseOrPhenotypicFeatureAssociation

Vincent Emonet

2022-09-16T11:51:44.115Z

http://purl.org/np/RAxAUvPgoe... RAxAUvPgoe

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

http://www.w3.org/2000/01/rdf-schema#label label

Currently, there are no FDA-approved pharmacotherapies available for CUD, though a number (eg, cannabinoids, antidepressants, anxiolytics, and glutamatergic modulators) have been proposed for off-label use. We identified 12 trials examining psychopharmacological interventions for the treatment of cannabis use disorder. Trials examined antidepressants (ie, escitalopram, fluoxetine, bupropion, nefazodone, venlafaxine, vilazodone), antipsychotics (ie, clozapine, ziprasidone), buspirone, mood stabilizers (ie, divalproex, lithium), and atomoxetine. Overall, studies found that antidepressants as a class were less effective than placebo for the achievement of abstinence (moderate SOE). There was no difference between antidepressants (moderate SOE) or buspirone (low SOE) and placebo in reducing overall cannabis use or retention in treatment. We found low strength evidence of no difference from placebo for antidepressants or buspirone on harms. Antidepressant medications did not impact secondary outcomes (low SOE). Findings for all other psychopharmacotherapies and drug/outcome combinations were either insufficient or were not identified in the current literature.

Vincent Emonet

2022-09-16T11:51:44.115Z

http://purl.org/np/RAxAUvPgoe... RAxAUvPgoe

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

http://www.w3.org/1999/02/22-rdf-syntax-ns#object object

http://purl.obolibrary.org/obo/MONDO_0005689 MONDO_0005689

Vincent Emonet

2022-09-16T11:51:44.115Z

http://purl.org/np/RAxAUvPgoe... RAxAUvPgoe

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate predicate

https://w3id.org/biolink/vocab/treats treats

Vincent Emonet

2022-09-16T11:51:44.115Z

http://purl.org/np/RAxAUvPgoe... RAxAUvPgoe

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

http://www.w3.org/1999/02/22-rdf-syntax-ns#subject subject

http://identifiers.org/drugbank/DB00472 DB00472

Vincent Emonet

2022-09-16T11:51:44.115Z

http://purl.org/np/RAxAUvPgoe... RAxAUvPgoe

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

https://w3id.org/biolink/vocab/has_population_context has_population_context

http://purl.org/np/RAxAUvPgoe...#context context

Vincent Emonet

2022-09-16T11:51:44.115Z

http://purl.org/np/RAxAUvPgoe... RAxAUvPgoe

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

https://w3id.org/biolink/vocab/category category

https://w3id.org/biolink/vocab...OrPhenotypicFeatureAssociation ChemicalToDiseaseOrPhenotypicFeatureAssociation

Vincent Emonet

2022-09-16T11:51:44.115Z

http://purl.org/np/RAxAUvPgoe... RAxAUvPgoe

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

https://w3id.org/biolink/vocab/aggregator_knowledge_source aggregator_knowledge_source

https://w3id.org/biolink/infores/knowledge-collaboratory knowledge-collaboratory

Vincent Emonet

2022-09-16T11:51:44.115Z

http://purl.org/np/RAxAUvPgoe... RAxAUvPgoe

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

https://w3id.org/biolink/vocab/publications publications

http://www.ncbi.nlm.nih.gov/pubmed/32227801 pubmed/32227801

Vincent Emonet

2022-09-16T11:51:44.115Z

http://purl.org/np/RAxAUvPgoe... RAxAUvPgoe

links a nanopublication to its assertion http://www.nanopub.org/nschema#hasAssertion assertion

https://w3id.org/biolink/vocab/relation relation

http://purl.obolibrary.org/obo/NCIT_C94303 NCIT_C94303

Vincent Emonet

2022-09-16T11:51:44.115Z