association (explore)

association

Full identifier: http://purl.org/np/RA59XSqRVPk2FrSKMfCxyHV_NVcPGekpLer0BEIbmIb74#association

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Minted in Nanopublication

RA59XSqRVP comment approve/disapprove edit as derived nanopublication create new with same template

This is a local identifier minted within the nanopublication. http://purl.org/np/RA59XSqRVP...#association This association http://www.w3.org/2000/01/rdf-schema#label has label (this is a literal)

"While alcohol induces an increase of dopamine, ondansetron reduces the release of the neurotransmitter by blocking the 5-HT3 receptors. Several studies investigated the effectiveness of ondansetron by dividing alcoholic individuals into two subgroups based on their genotype for the promoter region of the SLC6A4 gene coding for the serotonin transporter (5-HTTLPR L/S polymorphism). The study showed that the patients with the LL genotype treated with ondansetron responded better in terms of alcohol amount and days of abstinence, compared to the other subgroups. Based on these results, researchers have further investigated genotype LL carriers, by analyzing the role of a functional polymorphism of the SLC6A4 gene (rs1042173 [T/G] SNP). The result was that individuals who carry both 5-HTTLPR LL polymorphism and rs1042173 TT polymorphism, treated with ondansetron at the dosage of 0.5 mg/die, present a more effective response to the drug. Unfortunately, the sample of this exploratory study was too small to be validated."

This is a local identifier minted within the nanopublication. http://purl.org/np/RA59XSqRVP...#association This association http://www.w3.org/1999/02/22-rdf-syntax-ns#subject has drug https://identifiers.org/DRUGBANK:DB00904

DRUGBANK:DB00904

This is a local identifier minted within the nanopublication. http://purl.org/np/RA59XSqRVP...#association This association http://www.w3.org/1999/02/22-rdf-syntax-ns#object has disease http://purl.obolibrary.org/obo/DOID_1574

DOID_1574

This is a local identifier minted within the nanopublication. http://purl.org/np/RA59XSqRVP...#association This association https://w3id.org/biolink/vocab/relation has relation https://w3id.org/um/neurodkg/OffLabelIndication

An indication found in off-label drug uses

This is a local identifier minted within the nanopublication. http://purl.org/np/RA59XSqRVP...#association This association https://w3id.org/biolink/vocab/publications has publications https://pubmed.ncbi.nlm.nih.gov/29912214

pubmed.ncbi.nlm.nih.gov/29912214

This is a local identifier minted within the nanopublication. http://purl.org/np/RA59XSqRVP...#association This association http://www.w3.org/1999/02/22-rdf-syntax-ns#type has type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement association Statement .

This is a local identifier minted within the nanopublication. http://purl.org/np/RA59XSqRVP...#association This association http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate has predicate https://w3id.org/biolink/vocab/treats treats .

This is a local identifier minted within the nanopublication. http://purl.org/np/RA59XSqRVP...#association This association https://w3id.org/biolink/vocab/provided_by is provided by https://w3id.org/um/NeuroDKG NeuroDKG .

http://purl.obolibrary.org/obo/DOID_1574 DOID_1574 http://www.w3.org/1999/02/22-rdf-syntax-ns#type type https://w3id.org/biolink/vocab/Disease Disease .

This is a local identifier that was minted when the nanopublication was created. http://purl.org/np/RA59XSqRVP...#association association https://w3id.org/biolink/vocab/has_population_context has_population_context This is a local identifier that was minted when the nanopublication was created. http://purl.org/np/RA59XSqRVP...#context context .

This is a local identifier that was minted when the nanopublication was created. http://purl.org/np/RA59XSqRVP...#context context http://www.w3.org/1999/02/22-rdf-syntax-ns#type type https://w3id.org/biolink/vocab/Cohort Cohort .

This is a local identifier that was minted when the nanopublication was created. http://purl.org/np/RA59XSqRVP...#context context http://www.w3.org/2000/01/rdf-schema#label label "adults" .

https://identifiers.org/DRUGBANK:DB00904 DRUGBANK:DB00904 http://www.w3.org/1999/02/22-rdf-syntax-ns#type type https://w3id.org/biolink/vocab/Drug Drug .

This is the identifier for the assertion of this nanopublication. http://purl.org/np/RA59XSqRVP...#assertion The assertion above http://www.w3.org/ns/prov#generatedAtTime

generatedAtTime

(this is a literal)

"2021-08-26T09:18:24.960707"

(xsd:dateTime) .

This is the identifier for this whole nanopublication. http://purl.org/np/RA59XSqRVP... This nanopublication links to the assertion template that was used to create this nanopublication https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate was created from the assertion template http://purl.org/np/RAhNHZw6Ur...

RAhNHZw6Ur

This is a local identifier minted within the nanopublication. http://purl.org/np/RA59XSqRVP...#sig

sig

http://purl.org/nanopub/x/hasSignatureTarget has as target This is the identifier for this whole nanopublication. http://purl.org/np/RA59XSqRVP... this nanopublication .

This is a local identifier minted within the nanopublication. http://purl.org/np/RA59XSqRVP...#sig

sig

http://purl.org/nanopub/x/hasAlgorithm has the algorithm (this is a literal)

"RSA"

This is a local identifier minted within the nanopublication. http://purl.org/np/RA59XSqRVP...#sig

sig

http://purl.org/nanopub/x/hasPublicKey has the public key (this is a literal)

"MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCamPJb4SzqpLXn//XJ5dlVfzz6QI+RPmiJTLXF/by2JR7sHMKRsCQDFsYMlq8zGHghOIkjRP9dpLZUtZzUcHt3MXiFKEPo8eGzUe9p+JXKFC8xxkJr94z2vq6IdMf71Iu1GH8SeDAKt/DgYO4zNaw8VuXvxnZRewKZSA+u8zWPVwIDAQAB"

This is a local identifier minted within the nanopublication. http://purl.org/np/RA59XSqRVP...#sig

sig

http://purl.org/nanopub/x/hasSignature has the signature (this is a literal)

"HKO/6/WbH6tUaC0vBhS/q+EAWDcX+6Z11YP0zdctz1Vbb7g1MLWld46IbtKKqoEuI30DM9aK5UNbjEHrEkYaXal8+yk+OGuQi/5bAy/7i3ceSzsUT5sre6FuZJa/6KYJxDwW/tdYjcds8+F3hFttF+4/5FINgd33yqo4wLhfyrw="

This is the identifier for this whole nanopublication. http://purl.org/np/RA59XSqRVP...

this nanopublication

http://www.w3.org/ns/prov#generatedAtTime

generatedAtTime

(this is a literal)

"2021-08-26T09:18:24.960707"

(xsd:dateTime) .

This is the identifier for this whole nanopublication. http://purl.org/np/RA59XSqRVP...

this nanopublication

http://www.w3.org/ns/prov#wasAttributedTo

wasAttributedTo

https://orcid.org/0000-0002-7641-6446

0000-0002-7641-6446

0000-0002-7641-6446, 26 Aug 2021, 09:18:24 UTC

References

Raw

TriG(txt), JSON-LD(txt), N-Quads(txt), XML(txt)