@prefix this: <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .
@prefix sub: <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY#> .
@prefix schema: <https://schema.org/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix bl: <https://w3id.org/biolink/vocab/> .
@prefix nkg: <https://w3id.org/um/neurodkg/> .
@prefix ncit: <http://purl.obolibrary.org/obo/NCIT_> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix npx: <http://purl.org/nanopub/x/> .
@prefix prov: <http://www.w3.org/ns/prov#> .

<http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> a np:Nanopublication;
  np:hasAssertion sub:assertion;
  np:hasProvenance sub:provenance;
  np:hasPublicationInfo sub:pubinfo;
  dct:created "2021-08-16T11:00:00+01:00"^^xsd:dateTime;
  dct:creator orcid:0000-0002-1501-1082;
  npx:supersedes <http://purl.org/np/RA0w66ghERSs6kP8RKJyOvNdXgU51XwvqDOrKmOSlLfT4> .

<http://purl.obolibrary.org/obo/NCIT_C15675> rdfs:label "Adjuvant Therapy, any therapy that is administered to augment or stimulate other treatment modalities or to minimize or prevent disease recurrence subsequent to the main treatment plan. " .

sub:assertion a nt:AssertionTemplate;
  rdfs:label "Defining a drug indication with its context (BioLink model)";
  nt:hasStatement sub:st00, sub:st01, sub:st02, sub:st04, sub:st05, sub:st06, sub:st07,
    sub:st08, sub:st09, sub:st10, sub:st11, sub:st12, sub:st13, sub:st14;
  prov:wasAttributedTo orcid:0000-0002-1501-1082 .

sub:association a nt:LocalResource;
  rdfs:label "this association" .

sub:associationRelation a nt:GuidedChoicePlaceholder;
  rdfs:label "provide the type of drug indication";
  nt:possibleValue <http://purl.obolibrary.org/obo/NCIT_C15675>, schema:ApprovedIndication,
    schema:MedicalContraindication, schema:PreventionIndication, schema:TreatmentIndication,
    nkg:OffLabelIndication, nkg:SymptomaticReliefIndication .

sub:cohort a nt:LocalResource;
  rdfs:label "the study cohort" .

sub:cohortAgeLabel a nt:LiteralPlaceholder;
  rdfs:label "describe the life stage or age of the cohort (e.g. Adults)" .

sub:cohortAgeMax a nt:LiteralPlaceholder;
  rdfs:label "describe the maximum age of the cohort (e.g. 80)" .

sub:cohortAgeMin a nt:LiteralPlaceholder;
  rdfs:label "describe the minimum age of the cohort (e.g. 7)" .

sub:hasPhenotype a nt:GuidedChoicePlaceholder;
  rdfs:label "provide additional phenotypes for the cohort";
  nt:possibleValuesFromApi "https://name-resolution-sri.renci.org/lookup?limit=10&string=" .

sub:object a nt:GuidedChoicePlaceholder;
  rdfs:label "search for the disease it treats";
  nt:possibleValuesFromApi "https://name-resolution-sri.renci.org/lookup?limit=10&string=" .

sub:publication a nt:UriPlaceholder;
  rdfs:label "add the URL of a publication supporting this association (doi, PubMed...)" .

sub:readableassertion a nt:LiteralPlaceholder;
  rdfs:label "describe the assertion concisely (e.g. tylenol treats pain in adults patients)" .

sub:st00 a rdf:Statement;
  rdf:object sub:readableassertion;
  rdf:predicate rdfs:label;
  rdf:subject sub:association;
  nt:statementOrder 0 .

sub:st01 a rdf:Statement;
  rdf:object sub:subject;
  rdf:predicate rdf:subject;
  rdf:subject sub:association;
  nt:statementOrder 1 .

sub:st02 a rdf:Statement;
  rdf:object sub:object;
  rdf:predicate rdf:object;
  rdf:subject sub:association;
  nt:statementOrder 3 .

sub:st03 a rdf:Statement;
  rdf:object bl:ChemicalToDiseaseOrPhenotypicFeatureAssociation;
  rdf:predicate bl:association_type;
  rdf:subject sub:association;
  nt:statementOrder 19 .

sub:st04 a rdf:Statement;
  rdf:object sub:associationRelation;
  rdf:predicate bl:relation;
  rdf:subject sub:association;
  nt:statementOrder 6 .

sub:st05 a rdf:Statement;
  rdf:object <https://w3id.org/um/NeuroDKG>;
  rdf:predicate bl:provided_by;
  rdf:subject sub:association;
  nt:statementOrder 22 .

sub:st06 a nt:OptionalStatement;
  rdf:object sub:publication;
  rdf:predicate bl:publications;
  rdf:subject sub:association;
  nt:statementOrder 10 .

sub:st07 a nt:GroupedStatement, nt:OptionalStatement;
  nt:hasStatement sub:st07a, sub:st07b, sub:st07c;
  nt:statementOrder 11 .

sub:st07a a rdf:Statement;
  rdf:object sub:cohort;
  rdf:predicate bl:has_population_context;
  rdf:subject sub:association;
  nt:statementOrder 12 .

sub:st07b a rdf:Statement;
  rdf:object sub:cohortAgeLabel;
  rdf:predicate rdfs:label;
  rdf:subject sub:cohort;
  nt:statementOrder 13 .

sub:st07c a rdf:Statement;
  rdf:object bl:Cohort;
  rdf:predicate bl:category;
  rdf:subject sub:cohort;
  nt:statementOrder 14 .

sub:st08 a nt:OptionalStatement;
  rdf:object sub:cohortAgeMin;
  rdf:predicate schema:requiredMinAge;
  rdf:subject sub:cohort;
  nt:statementOrder 15 .

sub:st09 a nt:OptionalStatement;
  rdf:object sub:cohortAgeMax;
  rdf:predicate schema:requiredMaxAge;
  rdf:subject sub:cohort;
  nt:statementOrder 16 .

sub:st10 a nt:OptionalStatement, nt:RepeatableStatement;
  rdf:object sub:hasPhenotype;
  rdf:predicate bl:has_phenotype;
  rdf:subject sub:cohort;
  nt:statementOrder 18 .

sub:st11 a rdf:Statement;
  rdf:object rdf:Statement;
  rdf:predicate rdf:type;
  rdf:subject sub:association;
  nt:statementOrder 20 .

sub:st12 a rdf:Statement;
  rdf:object bl:Drug;
  rdf:predicate bl:category;
  rdf:subject sub:subject;
  nt:statementOrder 23 .

sub:st13 a rdf:Statement;
  rdf:object bl:Disease;
  rdf:predicate bl:category;
  rdf:subject sub:object;
  nt:statementOrder 24 .

sub:st14 a rdf:Statement;
  rdf:object bl:treats;
  rdf:predicate rdf:predicate;
  rdf:subject sub:association;
  nt:statementOrder 21 .

sub:subject a nt:GuidedChoicePlaceholder;
  rdfs:label "search for the indicated drug";
  nt:possibleValuesFromApi "https://name-resolution-sri.renci.org/lookup?limit=10&string=" .

rdf:Statement rdfs:label "association Statement" .

rdf:object rdfs:label "has disease" .

rdf:predicate rdfs:label "has predicate" .

rdf:subject rdfs:label "has drug" .

rdf:type rdfs:label "has type" .

rdfs:label rdfs:label "has label" .

schema:ApprovedIndication rdfs:label "An indication for a medical therapy that has been formally specified or approved by a regulatory body." .

schema:MedicalContraindication rdfs:label "A condition or factor that serves as a reason to withhold a certain medical therapy." .

schema:PreventionIndication rdfs:label "An indication for preventing an underlying condition, symptom, etc." .

schema:TreatmentIndication rdfs:label "An indication for treating an underlying condition." .

schema:requiredMaxAge rdfs:label "participant maximum age is" .

schema:requiredMinAge rdfs:label "participant minimum age is" .

bl:EvidenceType rdfs:label "EvidenceType" .

bl:association_type rdfs:label "has BioLink type" .

bl:category rdfs:label "is a" .

bl:description rdfs:label "is described by" .

bl:has_drug rdfs:label "uses drug" .

bl:has_phenotype rdfs:label "has phenotypes" .

bl:has_population_context rdfs:label "has population context" .

bl:id rdfs:label "has id" .

bl:negated rdfs:label "is negated" .

bl:provided_by rdfs:label "is provided by" .

bl:publications rdfs:label "has publications" .

bl:qualifiers rdfs:label "is qualified by" .

bl:relation rdfs:label "has relation" .

nkg:OffLabelIndication rdfs:label "An indication found in off-label drug uses" .

nkg:SymptomaticReliefIndication rdfs:label "An indication for only managing the symptoms of the condition" .

sub:sig npx:hasAlgorithm "RSA";
  npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCR9fz0fKCdWOWC+pxhkQhEM/ppbdIYe5TLSdj+lJzSlv9mYBaPgrzVezSwwbmhlHBPDZa4/vHycU315BdmUGq+pXllp9+rWFfrb+kBJwhZjpG6BeyyXBsRFz4jmQVxl/ZYHilQTh/XalYzKkEAyTiEMPee4Kz61PaWOKH24CsnOQIDAQAB";
  npx:hasSignature "iAatWmfjWSEn9Y+fQrjbn+LCcUdLV0Q3Wht3KH/7F35NuZyTI3dKqWrsg3qZrRLxOuL1Jdbkua8DgwZdSM3D5wY4Mb4ZGO14KD06Kok9FfRnOdjup0LXrg2a7enuXuLuexNnmKFVoC4AGrX8hrH8dE06II9wauAWL8FSY9OWMQI=";
  npx:hasSignatureTarget <http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY> .