Analyzing gene derulation in Huntington's disease with respect to epigenetic information
Science and technology/Natural science/Biology/Genetics
Economy, business and finance/Economy/Economic policy
Overall, the regional changes in gene expression areconsistent with the neuropathology in early grade HD, withcaudate being the most affected area, the cerebellum andBA cortex being relatively spared and the BA cortexshowing an intermediate pathology.
Health/Diseases and conditions/Mental and behavioural disorder
Economy, business and finance/Economic sector/Chemicals/Organic chemical
In addition we include all related to our experiment documents, papers and datasets
Huntington s disease (HD) pathology is well understood at a histological level but a comprehensivemolecular analysis of the effect of the disease in the human brain has not previously been available.
Regional and cellular gene expression changes inhuman Huntington s disease brain
Recently, regions with the sequence characteristics of CpG islands have been found associated with a number of genes, most of which are housekeeping genes (for reviews, see Cooper & Gerber Huber, ; Bird, ). Almost all CpG islands identified to date are associated with the ends of genes.
Science and technology/Technology and engineering/IT-computer sciences
growth hormone growth hormone releasing factor
Politics/Government/Defence/Armed forces
This RO is comprised by all workflows used for the integration and the analysis of Huntington's Disease (HD) gene expression data and epigenetic datasets in order to establish links between HD and epigenetic regulation in disease. In addition we include all related to our experiment documents, papers and datasets
Eleni Mina. "Analyzing gene derulation in Huntington's disease with respect to epigenetic information." ROHub. Aug 30 ,2013. https://w3id.org/ro-id/9c56e407-c5bc-45bd-8636-2f1066e10e75.
Huntington's disease gene deregulation is mediated by alterations in epigenetic mechanisms
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G/C boxes were found to be rare in CpG depleted DNA and plentiful in CpG islands, where they occurred in CpG islands, as well as in CpG islands associated with tissue specific and housekeeping genes.
Science and technology/Social sciences/Philosophy
Introduction within a gene was put forward by McClelland & In vertebrate DNA, the dinucleotide CpG occurs Ivarie ( ), who analysed a composite DNA at only . to . of the frequency expected from sequence derived from a number of mammalian the base composition (Josse et al., ; Swartz et genes.
This RO is comprised by all workflows used for the integration and the analysis of Huntington's Disease (HD) gene expression data and epigenetic datasets in order to establish links between HD and epigenetic regulation in disease.
Epigenetic phenomena are implicated in Huntington's disease gene deregulation
Analyzing gene derulation in Huntington's disease with respect to epigenetic information.